Observations on Megaloblastic Anaemias After Primidone

The megaloblastic anaemias.

Megaloblastic anaemias of gastrointestinal origin.

THERE exist two known anti-megaloblastic substances, vitamin B12 and folic acid. Both of these are absorbed from the small intestine and the body is dependent on their dietary supply to prevent abnormal changes in haemopoiesis. Deficiencies of these compounds may arise in a number of ways, but one important group arises from abnormalities of the small intestine interfering with normal absorptiv...

Aminoaciduria in the megaloblastic anaemias.

One-dimensional chromatography (Dent, 1946) was carried out on morning specimens of urine. Had results from this screening test indicated an excess or abnormal pattern of amino-acids, twodimensional chromatography would have been necessary for the identification of the amino-acids. Seven African women suffering from proven megaloblastic anaemia who were admitted between October, 1954, and Octob...

Megaloblastic anemia following the use of primidone.

HILE the umsderhyimmg causes of the nsajority of misegaloblast-ic amsemssias are usow knsown, the list is usotyet exhaustive amid it has recemstly been suggested that amsticomsvulsammt drutgs nsay commstitute a mies ’ etiohogic fact-or its sonic cases. The postulated effectof these drutgs is particutlarly strikimsg ins that megaloblastic ausemia is msot seems wit-h the niomispecific toxic agcmm...

The epithelial cells in megaloblastic anaemias.